Endocrine Abstracts

Anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies are a new class of biological drugs that inhibit binding of PCSK9 to the LDL receptor, thus increasing LDL-receptor density and lowering circulating LDL-cholesterol (LDL-C), apo-B100 and Lp(a). Recently released guidelines on management of hyperlipidemia reinforced the attribute of statins as the mainstay of lipid-lowering medication in dyslipidemic at-risk individuals, as every 1.0 mmol/L reducti...

Introduction: Thyroid carcinoma (TC) is the most common endocrine malignancy. Although the overall prognosis for patients with TC is good, up to 20% of patients develop recurrent or persistent disease after conventional therapy by total thyroidectomy and radioactive iodine (RAI). Amiodarone is a highly efficient anti-arrhythmic drug with a very long half-life, so it may interfere with RAI many months after the drug withdrawal. This case report mirrors the challenges of thyroid...

It has been shown that aging is associated with ‘physiological’ alterations in both the hypothalamo–pituitary–thyroid axis and at the peripheral level such as elevation of basal TSH levels, often with normal T3 and T4 levels and decreased nuclear binding of thyroid hormones, particularly of T3. The frequency of nodular goiter and of an altered thyroid status increases with advancing age. The aim of our study was to analyze t...

Periodontal changes are induced by hormonal alterations through soft tissue oedema, inflammation, demineralization or abnormal periosteal development of the alveolar bones.Objectives: The purpose of the present work was to evaluate the frequency, severity and type of periodontal disease in subjects with previously diagnosed and non-treated pituitary disorders.Patients and methods: Twenty-five subjects (21 women and 4 men) aged 44.7...

Introduction: Hirata disease (or Insulin autoimmune syndrome) is characterized by the presence of high concentrations of insulin autoantibodies leading to hyperinsulinemic hypoglycemia in individuals with no history of prior exposure to exogenous insulin. Etiopathogenesis is not completely elucidated, it’s considered to result from the interaction of genetic predisposition and environmental triggers such as: medications (methimazole, carbimazole, alpha-lipoic acid, captop...

Background: Resistance to thyroid hormone beta (RTHβ) is an inherited syndrome of reduced tissue responsiveness to thyroid hormones (THs). It is driven in 85% of cases by mutations in the thyroid hormone receptor beta (THRb). The estimated incidence is 1:40.000 to 1:19.000 live births. We report the clinical, laboratory, and genetic analysis of a patient with this disorder.Case report: A 12-year-old boy with a history of Attention-Deficit/H...

Aims: The effects of physical exercise on the endocrine system were monitored.Material and method: The study included 60 young and healthy subjects.The subjects were divided into two groups:– group A (30) performed anaerobic exercise for 50 minutes: running on the treadmill at a speed of 8 km/hour, walking on the treadmill at a speed of 5 km/hour, and running on the treadmill at a speed of 8 km/hour;...

Background and aims: The aim of this study is to analyse the serum markers of liver function and the morphological hepatic changes (by ultrasound) in hypo- and hyperthyroidism.Methods: The study included 59 patients with hypothyroidism: subclinical disease 14 patients and clinically manifest disease 45 patients, and 30 patients with hyperthyroidism. All patients underwent serum liver function tests: alanine aminotransferase (ALT), aspartate aminotransfer...

Intentional insulin overdose in diabetic patients is a rare critical situation. The severity is due to numerous neurological complications, electrolyte disturbances, liver and lung damage or death.Case report: A 65-year-old male, with significant cardiac and pulmonary pathology, diagnosed with type 2 diabetes since 1996 and treated with glargine (70 U/day) and aspart (68 U/day) insulin is admitted to our centre via ER (emergency room) after an episode of...

Introduction: Tumor-induced osteomalacia is a rare paraneoplastic syndrome characterized by the presence of phosphaturic hormone-secreting mesenchymal tumors - fibroblast growth factor 23 (FGF-23), which causes hypophosphatemia and osteomalacia. These tumors are small, frequently infiltrate the surrounding tissues and are located in the connective or bone tissue. Usually, these tumors are benign, but malignant tumors have also been reported.Case report: ...